Oncocytic metaplasia is a common but focal phenomenon in several other salivary gland neoplasms including acc, pleomorphic adenoma, mucoepidermoid carcinoma, and myoepithelioma, plasmacytoid type. It is usually advanced that the absence of an oncocytic hurthle cell variant of undifferentiated carcinoma utc. The oncocytic variant of papillary carcinoma of the thyroid represents an unusual neoplasm whose clinicopathological features and biological behavior have not been thoroughly characterized. Jun 30, 2012 oncocytic variant of prostatic adenocarcinoma is a very rare variant and to date very few cases have been reported4,5. Carcinoma, follicular oncocyticoxyphilic cell variant 99fp carcinoma, follicular poorly differentiated carcinoma, follicular trabecular type 99fw carcinoma, follicular well differentiated 99fc carcinoma, follicular, microinvasive 96gi carcinoma, giant cell 96gc carcinoma, glassy cell 93gl carcinoma, glycogenrich carcinoma, glycogen. Oncocytictype intraductal papillary mucinous neoplasm. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. The oncocytic variant of papillary carcinoma of the. Outside of the endocrine system, there is an oncocytic variant of renal cell carcinoma, and salivary glands, particularly the parotid, develop oncocytic nodules and tumours.
Department of pathology and laboratory medicine, university of vermont fletcher. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing. Pdf oncocytic variant of medullary thyroid carcinoma. Sixteen cases of primary oncocytic adenocarcinomas of the lung are reported. Oxyphilic and nonoxyphilic thyroid carcinoma cell lines. Oncocytic adenoma definition of oncocytic adenoma by. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Because of this focality, these tumors are rarely confused as oncocytic by fna cytology. Disease bioinformatics research of oncocytic metaplasia has been linked to metaplasia, neoplasms, oncocytic neoplasm, carcinoma, hyperplasia. The mean age at diagnosis was 43 years for adenomas and 52 for oncocytic carcinomas in a recent series. Whether youve loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. The concept of classifying oncocytic lesions, including follicular variant papillary carcinomas, based on.
Squamous and oncocytic metaplasia in salivary gland tumors j. Who classification of tumours of the urinary system and. Oncocytictype intraductal papillary mucinous neoplasm ipmn. Melanotic oncocytic metaplasia of the nasopharynx as a benign. Many investigators have suggested that these tumors originate from intercalated cells of the collecting system. Oncocytic tumours are found in the thyroid and other endocrine tissues, including the parathyroid, pituitary, adrenal cortex, pancreas, gut, and lung. A clinicopathologic study of minimally invasive follicular. Accumulation of p27kip1 is associated with cyclin d3 overexpression in the oxyphilic hurthle cell variant.
The study of oxyphilic adenocarcinoma has been mentioned in research publications which can be found using our bioinformatics tool below. The oncocytic variant of medullary thyroid carcinoma is rare. Numerous and frequentlyupdated resource results are available from this search. Variants of papillary thyroid carcinoma turkish journal of pathology. International classification of diseases for oncology. It comprises about 1% of all salivary gland tumors. This classification is widely used by cancer registries it is currently in its third revision icdo3. Oncocytic metaplasia in inflammatory fibrous hyperplasia med oral patol oral cir bucal. The oxyphilic hurthle cell type may be more aggressive than usual ptc. The follicular variant is less favorable than typical ptc. Asa suggests that is no logical basis to separate oncocytic lesions from other classifications of thyroid pathology j clin pathol 2004.
We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing the classical nuclear. Absence of the braf and the grim19 mutations in oncocytic. The oncocytic variant shows a papillary growth pattern with nuclear features of ptc combined with cytoplasm that is. Oncocytictype intraductal papillary mucinous neoplasm ipmn, first identified by ohhashi et al. Besides these defined neoplasms, there are other entities that are not well identified oncocytic changes of the parotid gland, such as oncocytic metaplasia, diffuse oncocytosis. In order to clarify if a different expression of apoptosisrelated genes could be responsible for dna fragmentation in oxyphilic cell tumors, two thyroid follicular carcinomaderived cell lines, having oxyphilic xtc. Earlier it was thought that hccs behave more aggressively than follicular carcinomas but later no statistically significant difference in the rate of local recurrence, metastasis, or patient survival was found. Plasma cells or lymphohistiocytic aggregates were not seen in this aspirate.
Pdf my approach to oncocytic tumors of the thyroid researchgate. Melanotic oncocytic metaplasia of the nasopharynx as a. All books videos on the med syndicate are free and. The true oncocytic cells are derived from follicular cells, whereas hurthle described parafollicular calcitoninproducing cells. Oxyphilic tumors of the thyroid are characterized by mitochondrionrich cells and extensive dna fragmentation. Atlas of endocrine pathology pdf download direct link. There is a female preponderance in both subgroups, with a femaletomale ratio of 8. The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing the classical nuclear features of papillary carcinoma of the thyroid. Mediakit reprints and eprints sponsored supplements branded books.
Thyroid oncocytic tumors represent approximately 510% of thyroid neoplasms. Oncocytic metaplasia in inflammatory fibrous hyperplasia. Primary oncocytic adenocarcinomas of the lung american journal. The international classification of diseases for oncology icdo is a domainspecific extension of the international statistical classification of diseases and related health problems for tumor diseases. Oncocytic variant of medullary thyroid carcinoma a case. Make an appointment with your doctor if you have any signs or symptoms that worry you. Predictive value of the fineneedle aspiration diagnosis. Intraductal oncocytic papillary neoplasm iopn is a rare subset of intraductal. On fine needle aspiration cytology fnac, a hurthle cell neoplasm was suggested.
Oclcs webjunction has pulled together information and resources to assist library staff as they consider how to handle. Jan 30, 2020 these signs and symptoms dont necessarily mean you have hurthle cell cancer. The oncocytic variant of papillary thyroid carcinoma. Oncocytic carcinoma oncocytic carcinoma is a rare tumor, found mainly in the parotid gland. Oncocytic cells of the thyroid was first described by askanazy but are also known as hurthle or oxyphilic cells 30. Hurthle cell thyroid gland only oxyphilic cell, apocrine metaplasia breast gland only.
Several variants of papillary carcinoma have been described considering. In addition, other tumors or subtypes of tumors with oncocytic features include warthin tumor, the oncocytic variant of mucoepidermoid carcinoma, pleomorphic adenoma with oncocytic features, oncocytic carcinoma, and metastatic tumors, especially renal cell carcinoma. Melanotic variant of oncocytic metaplasia of the nasopharynx is an extremely rare condition. Random cytochromecoxidase deficiency of oxyphil cell nodules in the. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing the classical nuclear features. Hurthle cell cancer symptoms and causes mayo clinic. The nodules were biopsied to determine the histology. Disease bioinformatics research of oxyphilic adenocarcinoma has been linked to carcinoma, neoplasms, thyroid neoplasm, oncocytic neoplasm, malignant neoplasms. Oncocytic papillary thyroid carcinomas show accumulation of mitochondrial dna mutations.
Oxyphilic definition of oxyphilic by medical dictionary. The study of oncocytic metaplasia has been mentioned in research publications which can be found using our bioinformatics tool below. Oncocytic type intraductal papillary mucinous neoplasm ipmn, first identified by ohhashi et al. Oncocytic and oncocytelike lesions of the head and neck. Other readers will always be interested in your opinion of the books youve read. The clinical differential diagnosis was malignant melanoma or hemangioma. Oncocytic changes are seen in other thyroid cancer hurthle cell carcinoma, medullary carcinoma and in other variants of papillary carcinoma tall cell variant, warthinlike variant ptc variants with oncocytic changes may have overlapping morphology and patterns. Oxyphilic oncocytic change may occur as a focal finding in conventional ptc or may be more widespread in 3 uncommonrare variants. A 73yearold japanese man presented with nasal congestion and chill. Poorly differentiated and undifferentiated thyroid carcinomas. Hurthle cell carcinoma, a variant of follicular thyroid carcinoma. Oncocytes are large cells with abundant eosinophilic granular cytoplasm.
Information and translations of oncocytic in the most comprehensive dictionary definitions resource on the web. Pituitary metastases from the oncocytic variant of follicular. Pituitary metastases from the oncocytic variant of. In the thyroid gland, the oncocytic cell is considered to be a synonym for hurthle, oxyphilic, eosinophilic, or askanazy cell. No prognostic significance has been associated with it because there are not enough cases to be followed up. According to the most recent world health organization who classification, the current correct term for hcc is actually oncocytic carcinoma. Seroustype acini of a parotid gland with dense secretory granules histologic section of a submaxillary gland. Oncocytic tumours composed predominantly or exclusively of oncocytic cells are rare. Here we present the case of a 36yearold male patient with complaints of neck swelling and dysphagia. Portion of a parotid gland demonstrating multiple foci of sebaceous differentiation. Oncocytic change, either focal or diffuse, is a rare feature of mucoepidermoid carcinoma. Who classification of tumours of the urinary system and male genital organs is the eighth volume in the 4th edition of the who series on histological and genetic typing of human tumours. Lateral neck dissection was performed in 5 24% oncocytic variant and classical ptc patients, with metastatic lymphadenopathy found in four a median of four malignant lymph nodes. The oncocytic variant of papillary carcinoma of the thyroid.
This is a recent advances in histopathology presentation on metaplastic changes and abnormal behaviour of glands. Oncocytic variant of medullary thyroid carcinoma is an extremely rare entity and only 17 cases have been reported in the literature until 8 1 f 54 single lesion nd dominguez malagon et al. Oncocytic metaplasia in inflammatory fibrous hyperplasia oncocytic metaplasia in inflammatory fibrous hyperplasia. The oncocytic variant of mtc is an extremely rare diagnosis, with less than 20 cases reported. Oncocytic variant of medullary thyroid carcinoma is an extremely rare entity and only 17 cases have been reported in the literature until 8 1 f 54 single lesion nd dominguez malagon et. The first case of renal oncocytoma was reported by zippel in 1942. Clear cell variant of fibrolamellar carcinoma of the liver. Oxyphilic oncocytichurthle cell variant of ptc solid variant of ptc tall cell variant of ptc columnar variant of ptc hobnail variant of ptc references. Sep 01, 2001 fibrolamellar carcinoma of the liver is an uncommon but distinctive type of hepatocellular carcinoma hcc first described by edmondson in 1956 and later popularized in the 1980s by berman et al1 and craig et al.
Braf v600e mutation can be found in oncocytic papillary thyroid carcinoma but is much more prevalent in tall cell variant of papillary thyroid carcinoma. Jan 16, 2014 by light microscopy, hurthle cells refer to modified follicular cells exhibiting abundant finely granular cytoplasm, a round nucleus, and a variably conspicuous nucleolus. Fibrolamellar carcinoma of the liver is an uncommon but distinctive type of hepatocellular carcinoma hcc first described by edmondson in 1956 and later popularized in the 1980s by berman et al1 and craig et al. Oncocytic oxyphilic, hurthle cell like cytoplasm but nuclear features of papillary carcinoma. The new 4th edition world health organization classification for. However, formatting rules can vary widely between applications and fields of interest or study. Cribriformmorular variant of ptc warthinlike variant of ptc diffuse sclerosing variant of ptc oxyphilic oncocytic hurthle cell variant of ptc solid variant of ptc tall cell variant of ptc columnar variant of ptc hobnail variant of ptc references. They may be indications of other medical conditions such as inflammation of the thyroid gland or a noncancerous enlargement of the thyroid goiter. A normal human thyroid gland contains 20 to 30 million spherical follicles lined with follicular epithelial cells filled with colloid and stores a 3 months supply of thyroid hormone. Histopathological and immunohistochemical analysis. Oncocytic variant of prostatic adenocarcinoma is a very rare variant and to date very few cases have been reported4,5. Hccs with strongly eosinophilic and granular cells form the oxyphilic and oncocytic variants of hcc, the latter having increased number of. Tallcell carcinoma is a more aggressive form of thyroid carcinoma that differs from the usual form by showing tall columnar cells. Minimally invasive follicular thyroid carcinoma can be diagnosed when there is up to full capsular invasion, small.
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